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Clive N Svendsen Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

1/2018Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells.
1/2018Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis.
4/2014Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats.
8/2013Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.
7/2010Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease.
12/2008Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.
1/2008GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys.
1/2008Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease.
2/2006Crossroads in GDNF therapy for Parkinson's disease.
2/2005Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.
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Clive N Svendsen Research Topics

Disease

16Neurodegenerative Diseases (Neurodegenerative Disease)
01/2020 - 01/2002
13Parkinson Disease (Parkinson's Disease)
01/2022 - 09/2002
11Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2022 - 04/2008
7Huntington Disease (Huntington's Disease)
01/2019 - 01/2008
5Disease Progression
07/2017 - 12/2008
4Neoplasms (Cancer)
12/2021 - 10/2009
3Nervous System Diseases (Neurological Disorders)
01/2022 - 10/2010
3Allan-Herndon-Dudley syndrome
01/2022 - 01/2021
3Alzheimer Disease (Alzheimer's Disease)
11/2021 - 10/2010
3Wounds and Injuries (Trauma)
10/2017 - 02/2010
3Macular Degeneration (Age-Related Maculopathy)
05/2016 - 02/2015
3Retinal Degeneration
03/2016 - 03/2007
2COVID-19
01/2021 - 01/2020
2Inflammation (Inflammations)
06/2020 - 12/2014
2Infections
04/2020 - 01/2020
2Stroke (Strokes)
05/2016 - 06/2011
2Spinal Cord Injuries (Spinal Cord Injury)
05/2016 - 10/2015
2Retinitis Pigmentosa (Pigmentary Retinopathy)
03/2016 - 02/2015
2Ataxia Telangiectasia (Louis Bar Syndrome)
09/2015 - 12/2014
1Inborn Genetic Diseases (Disease, Hereditary)
01/2022
1Frontotemporal Dementia (Semantic Dementia)
01/2020
1Blindness (Hysterical Blindness)
01/2019
1Disease Susceptibility (Diathesis)
01/2019
1Corneal Injuries
10/2017
1Dementia (Dementias)
01/2017
1Synucleinopathies
01/2017
1Body Weight (Weight, Body)
12/2016
1Tauopathies
12/2016
1Peripheral Nervous System Diseases (PNS Diseases)
05/2016
1Demyelinating Diseases (Demyelinating Disease)
05/2016
1Retinal Diseases
02/2015
1Metatropic dwarfism
07/2014
1Limbal Stem Cell Deficiency
01/2013
1Motor Neuron Disease (Primary Lateral Sclerosis)
10/2011
1Hyperalgesia
01/2011
1Pain (Aches)
01/2011
1Glioma (Gliomas)
11/2010
1Glioblastoma (Glioblastoma Multiforme)
11/2010
1Brain Neoplasms (Brain Tumor)
11/2010
1Chorea (Rheumatic Chorea)
07/2010
1Trisomy (Trisomies)
10/2009
1Brain Diseases (Brain Disorder)
01/2008
1Brain Injuries (Brain Injury)
01/2008
1Ganglion Cysts (Ganglion)
05/2005
1Necrosis
02/2005
1Drug-Induced Dyskinesia (Dyskinesia, Drug Induced)
05/2003
1Down Syndrome (Down's Syndrome)
01/2002

Drug/Important Bio-Agent (IBA)

12Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
01/2018 - 05/2003
10Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2002
5Pharmaceutical PreparationsIBA
01/2019 - 10/2010
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2014 - 01/2008
3Thyroid HormonesIBA
01/2022 - 01/2021
3polyglutamineIBA
01/2017 - 07/2010
3Dopamine (Intropin)FDA LinkGeneric
01/2017 - 09/2002
2SynucleinsIBA
01/2022 - 01/2017
2alpha-SynucleinIBA
01/2022 - 03/2007
2Phosphotransferases (Kinase)IBA
01/2021 - 12/2014
2Antiviral Agents (Antivirals)IBA
04/2020 - 01/2020
2Retinaldehyde (Retinal)IBA
01/2019 - 05/2005
1Biological ProductsIBA
01/2022
1Triiodothyronine (Liothyronine)FDA LinkGeneric
01/2022
1Apolipoprotein E4IBA
11/2021
1Glutamic Acid (Glutamate)FDA Link
01/2017
1salicylhydroxamic acid (SHAM)IBA
12/2016
1Rhodopsin (Visual Purple)IBA
03/2016
1RNA (Ribonucleic Acid)IBA
03/2016
1Therapeutic UsesIBA
01/2016
1Histones (Histone)IBA
09/2015
1Retinal Pigments (Pigments, Visual)IBA
08/2015
1Superoxide Dismutase-1IBA
02/2015
1Ataxia Telangiectasia Mutated ProteinsIBA
12/2014
1Calcium Channels (Calcium Channel)IBA
07/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2013
1SteroidsIBA
05/2012
1NeurosteroidsIBA
05/2012
1Dehydroepiandrosterone (DHEA)IBA
05/2012
1Amyloid (Amyloid Fibrils)IBA
01/2012
1Choline O-Acetyltransferase (Choline Acetyltransferase)IBA
01/2012
1Cytotoxins (Cytolysins)IBA
11/2010
1Antineoplastic Agents (Antineoplastics)IBA
11/2010
1Epidermal Growth Factor (EGF)IBA
10/2009
1Insulin-Like Growth Factor I (IGF-1)IBA
01/2008
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
02/2005
1Nerve Growth Factors (Neurotrophins)IBA
05/2003
1RE1-silencing transcription factorIBA
01/2002
1Transcription Factors (Transcription Factor)IBA
01/2002

Therapy/Procedure

17Transplantation
12/2021 - 09/2002
16Therapeutics
01/2021 - 01/2002
4Stem Cell Transplantation
10/2018 - 06/2011
1Deep Brain Stimulation
01/2021
1Precision Medicine
01/2019
1Refractive Surgical Procedures
10/2017
1Cell- and Tissue-Based Therapy (Cell Therapy)
09/2014
1Castration
05/2012
1Cell Transplantation
01/2011
1Punctures
02/2010
1Heterologous Transplantation (Xenotransplantation)
10/2009
1Activities of Daily Living (ADL)
02/2005